Decreased expression of Sirt1 contributes to ocular Behcet’s disease progression via Th17 and Th22 response
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چکیده
منابع مشابه
SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression
Methyl-CpG binding protein 2 (MeCP2) binds methylated cytosines at CpG sites on DNA and it is thought to function as a critical epigenetic regulator. Mutations in the MeCP2 gene have been associated to Rett syndrome, a human neurodevelopmental disorder. Here we show that MeCP2 is acetylated by p300 and that SIRT1 mediates its deacetylation. SIRT1, the mammalian homologue of Sir2 in yeast, is a ...
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INTRODUCTION The aim of this study was to characterize interleukin 17 (IL-17) and interleukin 22 (IL-22) producing cells in peripheral blood (PB), skin, synovial fluid (SF) and synovial tissue (ST) in patients with psoriasis (Ps) and psoriatic arthritis (PsA). METHODS Flow cytometry was used to enumerate cells making IL-22 and IL-17, in skin and/or SF and PB from 11 patients with Ps and 12 pa...
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OBJECTIVE To determine the symptoms experienced by patients diagnosed with Behcet's Disease and how they cope with them. METHODS The qualitative study was conducted from September 2013 to March 2014 at Ege University Medical Faculty Hospital, Turkey, comprising patients having all symptoms of Behcet's Disease. Data was collected through semi-structured focus-group interview form. The findings...
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ژورنال
عنوان ژورنال: Ophthalmic Research
سال: 2020
ISSN: 0030-3747,1423-0259
DOI: 10.1159/000512754